The coronavirus has now killed 827 persons in Italy, with 196 new deaths recorded in the last couple of hours.
According to the Civil Protection Agency, the total number of cases in the country has also risen from 10,149 to 12,462.
The death toll is the largest in a day since the outbreak started in December 2019, extending the country’s record of 168 deaths in 24 hours.
Italy is the second worst hit from the virus in the world, after China, where it broke out in December.
The Italian government already extended its emergency measures, which include restrictions on travels and public gatherings, to the entire country.
It had also ordered a lock down in the entire northern region which has a population of 16 million people to check the spread of the disease.
Earlier on Wednesday, the World Health Organisation (WHO) declared the global coronavirus outbreak a pandemic, demanding more action from countries.
Tedros Ghebreyesus, its director-general, had said in the past two weeks, the number of infections from the virus has increased 13-fold outside the outbreak epicentre in China, while the number of affected countries has tripled.